Rare protection against type 1 diabetes

Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes

Elevated plasma triglyceride (TG) levels are an established risk factor for type-2 diabetes (T2D). However, recent studies have hinted at the possibility that genetic risk for TG may paradoxically protect against T2D. In this study, we examined the association of genetic risk for TG with incident T2D, and the interaction of baseline TG with TG genetic risk on incident T2D in 13,247 European-Ame...

Can we vaccinate against Type 1 diabetes?

Vaccination is the administration of antigenic material to stimulate the immune system to develop adaptive immunity to a disease. As the most successful prophylactic in medical history, there is now an emerging interest as to whether vaccination can be applied in autoimmune and inflammatory conditions. These are diseases of failed immune regulation; vaccination in this context aims to exploit t...

Protection Against Type 1 Diabetes Upon Coxsackievirus B4 Infection and iNKT-Cell Stimulation

Invariant natural killer T (iNKT) cells belong to the innate immune system and exercise a dual role as potent regulators of autoimmunity and participate in responses against different pathogens. They have been shown to prevent type 1 diabetes development and to promote antiviral responses. Many studies in the implication of environmental factors on the etiology of type 1 diabetes have suggested...

Sulfhydryl protection against dehydroascorbic acid diabetes.

Dehydroascorbic acid has been shown to produce diabetes (1, 2). In this respect it is similar to alloxan (3). Whereas alloxan has not yet been shown to occur physiologically, dehydroascorbic acid is accepted as occurring under physiological conditions in the cells of animals (4). Therefore, it is important to study the factors that are known to affect alloxan diabetes in order to determine thei...

Autoantibodies against multiple tissues in type 1 diabetes.